Instructional Strategies Concept Research Paper

Instructional Strategies Concept - Research Paper Example He agreed to work with Dr. Cynthia for designing an instructional material with a list of suggestions and delivery method of the same. However, according to the study, Clifford, the experienced instruction designer found Dr. Cynthia to be his toughest client in his career. He faced a number of difficulties in designing the material and till date he has not been able to complete any normal ID task of his (Ertmer and Cennamo, n.d.). Challenges faced by the instructional designers Clifford lacked the essential data of learner’s characteristics, which is the most important information an instruction designer needs to develop the pattern of instruction (Ertmer and Cennamo, n.d.). Most designers put stress on learners and learning outcomes prior to the designing of instruction. The learning process complexities and several critical human dimensions are required to be understood by designers which come into play. Learners carry a wealth of experiences and traits with them to a training setting or education that play a significant part in measuring the success of the instruction. It also includes normal profile factors that tell about the learners’ background, capability and several attitudinal factors. Many of these factors have notable impacts on the learners’ motivation to learn. A basket of prerequisite skills and knowledge are also brought by the learners to the instructional setting. These entry skills are highly related to the content of a particular instructional experience (Richey, James, Klein, and Tracey, 2010. p.170). The second problem faced by Clifford was regarding contextual analysis. In spite of having four meetings with Oakes, Clifford could not gather the necessary important information that could help him during contextual analysis (Ertmer and Cennamo, n.d.). Contextual analysis plays a key role in designing and developing instructions for learning. Instructional context provides rich data about real world scenario and examples. There are few reasons that necessitate analysis of context. First, every aspect of the leaning experiences is influenced by context. Second, Context as a collection of factors can facilitate or inhibit instruction and learning. Third, multiple contexts can be required a by single classroom. For example, sixth grade students might need to do survey in neighboring historical buildings, do research in computer lab and in historic society and arrange a meeting in a hallway in a pro blem based learning approach. An instructional designer should analyze three types of contexts. They are orienting context where learner is focused primarily, instructional context that suggests about the scheduling and physical environment of the training and another is transfer context, which enables the opportunities for transferring the skills and knowledge to new situations (Morrison, Ross, Kalman, and Kemp, 2011, pp.65-66). Although Clifford did have his notes and resources from the four meetings with Oaks, but it just did seem remotely related to his assignment (Ertmer and Cennamo, n.d.). As a result, he could not create an objective domain. Objective domains are classifications or categories of objectives that helps instructional designers for determining several important elements of design. There are four domains of objective such as, cognitive, affective, psychomotor and interpersonal. These help designers to determine how to structure evaluations, objectives and delivery system. For an example, an instructional designer was working on training system for technicians for repairing a certain type of computer. It might require usage all the four domains. Such as,

Enriques Journey Essay Example for Free

Enriques Journey Essay Just as Enrique arrives, there is tension between his mother and him. They begin to argue about how Enrique had developed bad habits such as drinking and staying out late as well as sniffing glue. These problems do not surprise me because he had been through alot on his intense journey all the way from Honduras. It hurt Lourdes to see her son do nothing but hurt himself and her family because the money he was spending on alcohol should have been sent back home to help pay for school. Enrique also put his mother down by constantly making her feel guilty for leaving and that she did not deserve to call herself his mother. Looking back at the relationship between them before she left, I thought that their relationship would have been stronger than ever after not seeing each other for years and that he would appreciate the fact that he found her unlike many of the other immigrants that search for years and are still unable to find their family members. Enriques motivation to stay in the United States is work and buy a house back in Honduras not to mention the amount of money he is making allows him to afford a lot more than he could back in Honduras. He wishes to continue working so he can support his girlfriend and his daughter back home in Honduras as well as buy a house so that he can move in with his girlfriend and daughter and finally be a family. He thinks that his girlfriend is cheating on him and he realizes that he wants to be there for his daughter and raise her before she calls someone else her father. Rather than Enrique moving back home he decides that he wants his girlfriend and the baby to move to the United States with him. I believe that there is so much conflict between Enrique and Lourdes is because Lourdes is trying to mother and discipline Enrique when she was not there raise him so he feels as if she is not his mother anymore. If she had not left and raised her family as her own they would not have any problems with their relationship and most likely Enrique would have not got himself into trouble by abusing drugs and drinking too much. I believe once Enrique begins to pick up his act and stops abusing drugs and drinking and coming home late his relationship with his mother would become better as well as eing able to function the next day and able to perform well at work so he can earn enough to visit his family back home in Honduras. I believe that Enrique made the correct decision coming to the United States, although he put his life in danger he reached his goal and finally got to see his mother after many years. Despite making the same mistake as his mother and leaving his girlfriend and daughter for a job to help pay for their needs, I believe it is necessary because if Enrique was back home there was a chance he could not have even had a job and then he would have had no way to support his family. He gained many things by coming to the United States. He had an opportunity to provide a decent living for his family as well as reuniting with his mother even though it was not easy for them at first. Enrique, on his journey, lost his sense of pride. After being harassed by so many times by the local police, he had nothing left to the point where it would have made no difference if he had died. He is in jeopardy of losing his family being many thousands of miles away from them, his girlfriend could leave him for someone who is making a better living in Honduras and would be able to be there to help raise their kids.

The Biopharmaceuticals An Overview Biology Essay

The Biopharmaceuticals An Overview Biology Essay Biopharmaceuticals are defined as proteins and nucleic acids which are used for therapeutic purpose. These are high molecular weight substances prepared by biotechnological means and genetically engineered. Due to their complex structure and intricate molecular composition it is very difficult to characterize and formulate such products. Most of these products are derived from biological species and genetically engineered to produce a potent compound [1-3]. Humulin (biosynthetic recombinant human Insulin) was the first biopharmaceutical product developed by Genentech but licensed and marketed by Eli Lily and Company in 1982. In the modern era biopharmaceutical products have become a major facilitating reason of technological changes in health care sector, causing extraordinary benefits for patients, cost challenges for consumers, and profits for market shareholders.[4] Over the last decade biopharmaceutical market is the fastest growing segment in the pharmaceutical organizations. After post-recession period vigorous advancement has been seen in this area. It has been reported that approximately 40% of total pharmaceutical RD investment is occupied by biopharmaceutical products amongst which, monoclonal antibodies and product produced by recombinant DNA method are the most prevalent one.[5,6] Proteins with different amino acid sequences are the primary structure of such products. For determining the biological activity of a protein it is necessary to study its three-dimensional structure. The structure of protein is generally divided into four categories i.e. primary, secondary, tertiary and quaternary (fig. 1). The primary structure is the sequence of amino acid residues which folds and stabilized by the formation of hydrogen bonds with subsequent molecules in the polypeptide chain to produce an  ÃƒÅ½Ã‚ ± helix,  which is a spiral, rod-like st ructure, or a  ÃƒÅ½Ã‚ ² sheet,  a planar structure. This structure resembles to the secondary structure of proteins. The tertiary structure is a three-dimensional arrangement which gives an overall conformation of a polypeptide chain. Through hydrophobic interactions between the non-polar side chains and disulfide bonds, this tertiary structure is stabilized. A quaternary or multimeric protein contains two or more polypeptide chains, held together by non-covalent bonds.[7] fig 1. Structure of protein. Because of their unique physicochemical characteristic it is very hard and challenging to formulate biopharmaceuticals as products with therapeutic effects and storage characteristics. Meanwhile their formulation is in many ways different from conventional low-molecular drug formulation. Despite of such facts biopharmaceuticals gains lots of attention in the modern era of drug formulation. In the recent reviews it has been discussed that around 400 biotechnology-based medicinal and therapeutic agents are either registered or in the clinical trials are reviewed by the regulatory bodies. These agents are helpful in treating many life threatening diseases some of them are cancer, infectious diseases, autoimmune diseases, and AIDS/HIV. Some of the agents which are already in the market are monoclonal antibodies, recombinant hormones, cytokines, vaccines, recombinant blood factor, and therapeutic enzymes.[5] Discussion Biopharmaceutical market In 1970, discovery of recombinant DNA technology and monoclonal antibodies lead to initiate the development of biopharmaceutical industries. A substantial growth from $8 billion in 1992 to $149 billion in 2010 quenched the thirst of investors towards the biopharmaceutical industry. It is expected to reach $239 billion by 2015 with a growth rate of 9.9% annually. There are more than 400 Biotech drugs and vaccines are scrutinized under clinical stage, targeting more than 200 diseases. Meanwhile a large number of the population is now taking benefits from a number of biotechnological innovations like recombinant protein-based products e.g. monoclonal antibodies and some large molecule prescription drugs, which include hormones and vaccines. Table 1 illustrates some of the leading biopharmaceutical therapy classes by size worldwide in 2002. In 2008 approximately 39%, among the top 10 drugs sold globally, are biopharmaceuticals and is expected to rise to 79% of the top 10 drug sales by 20 14.[8] Table.1: Leading biopharmaceutical therapy classes by size worldwide 2002. Source: IMS MIDAS December 2002. However after the post recession period, fundings over health care and other sector is reduced which impede the growth rate of pharmaceutical industries up to significant extent. Although biopharmaceutical global sales thrive to attain high numbers in the global health sector. Biotechnological based products have generated $229 billion revenue in 2012 with an annual growth rate of 10.4%. Meanwhile the major focus of pharmaceutical organizations is on biopharmaceutical vs. Small molecule drugs which enables to allocate high funding towards this area. This may be due to very less generic biosimilar products available in the market. In year 2009 there are total 18 biopharmaceutical products are approved by US FDA which is higher than the previous years i.e. 11 in 2008 and 10 in 2007. In a report of Battelle Technology Partnership Practice, it was estimated that the overall impact of biopharmaceutical sector on the US economy is $917 billion. These companies are making alliances with oth er essential services such as computing and information, clinical trial and regulatory support services, technologies, manufacturing and equipment, and transportation and logistics providers.[9-11] Types of Biopharmaceuticals Cytokines Cytokines are a diverse group of non-antibody intercellular signalling regulatory proteins i.e. glycoprotein and low molecular weight peptides produced in very little amount inside the body. They function as a mediator for communication between various cells and induce certain response by binding to specific cell surface receptors which results in triggering various intracellular signal transduction mechanism. There are over 80 sub class of cytokines have been found. Some of these are categorized in table 2. They play an important role in coordinating embryonic development, cell growth and maturation, wound repair and healing, the immune response including acute phase reactions and septic shock, and new blood vessel formation. Cancer is among the major class of disease which is thoroughly scrutinized by the researchers with an emphasis on cytokines. However cytokines also play a vital role in mediating signalling response to systemic inflammation which tends to regulate specific neur onal network to induce sickness. Some animal studies reveal the role of cytokines in situations characterized by abnormal sleep, with emphasis on the pathogenesis of symptoms and consequences of OSAS (Obstructive sleep apnoea syndrome). Cytokines interact with specific cells via (1) intracrine, in which both cytokine and receptor remain within the cell (rare); (2) autocrine, where a cytokine acts on the receptors of the same cell it is produced; and (3) paracrine, where the cytokine from one cell type interacts with receptors on other cell types.[12-16] Table 2: categorization of cytokines. There are various cytokines products available in the market and some of them are reviewed under the clinical phase for example Interleukin-2 (IL-2) aldesleukin (Proleukin), for treating renal cell carcinoma is approved by FDA. IL-1 blocker, anakinra (Kineret) and rilonacept (Arcalyst) are used for the treatment of rheumatoid arthritis and cryopyrin-associated periodic syndromes respectively.[1] Enzymes Enzymes are complex molecules produced by living cells. They increase the rate of chemical reaction without even showing their own effect in the process and hence act as a catalyst in living organisms.[17] Because of their reaction specificity, catalytic efficiency and ability to operate under mild condition of temperature and hydrogen ion concentration they are preferred as a novel class of therapeutic agents. Despite of their therapeutic role enzyme endures significant importance as a replacement therapy in many genetic disorders. However there are some disadvantages as well associated with their use such as, their parental administration required extensive purification to remove contaminants. They are also very costly to prepare and due to their large molecular structure they have limited distribution in the body. As they are proteins hence when administered inside the body act as antigen to the host cell.[18,19] Enzymes are categorized under six major classes i.e transferases, lysases, hydrolases, isomerases, ligases, and oxidoreductases. The potential utility of enzyme as pharmaceutical was noted many decades ago. However most of the enzyme therapies are used to treat functional defects. Activase ® (alteplase; recombinant human tissue plasminogen activator), is the first recombinant enzyme drug which was approved by the Food and Drug Administration in 1987. Pulmozyme ® (Dornase alpha), a recombinant DNAse I that digests DNA in the mucous secretions in lungs, used to treat cystic fibrosis. Adagen ® (pegadamase bovine), is the first marketed product as enzyme therapy for the treatment of SCID (severe combined immunodeficiency disease).[20] Hormones Hormone is characterized as an important group of regulatory molecule which is synthesized in an organ or in tissue and then secreted into circulatory system where it affects respective organs whose cell bears an appropriate receptors. They are chemical messengers either small or a large macromolecule and are fairly defined as endocrine hormones. Approximately all endocrine hormones possess therapeutic importance and hence subsequently used by the researchers e.g. insulin(Insugen ®, Humulin ®, Novolin ®), human growth hormone (Ascellacrin ®, Crescormon ®), glucagon, and the gonadotrophins.[1] Antibodies: Antibodies or immunoglobulin are proteins produced, as an immune response, through white blood cells when a foreign particle or antigen intrudes inside the body. There are five classes of immunoglobulin IgE, IgM, IgG, IgD, and IgA. Amongst them IgG is the most common as a biopharmaceutical agents. A more specified term i.e. monoclonal antibodies (mAb  or  moAb) are the novel class compounds that are first developed in mid 1970s by kohler and Milstein, who successfully fused immortal cells with antibody- producing B lymphocytes. This fusion results in a hybrid which is stable, cancerous, antibody- producing cells. These are referred as hybridoma cells which unveil great source of monoclonal antibody. mAb identify antigens on a particular foreign body very specifically. mAbs are categorized under four groups according to their source: murine (derived solely from mice), chimeric (mixture of murine and human sequences), humanised (contain over 90% human sequences) and fully human.[8, 17] In 1986, Murobmonab (OKT3), a murine antibody, is the first monoclonal antibody tested as a therapeutic in humans. However it fails to produce a substantial response in the transplantation rejection patients because of production of anti-murine antibody.[20] Monoclonal antibodies are the fastest growing therapeutic class in the field of biopharmaceutical market. The market of monoclonal antibodies crosses the mark of $30 billion in 2011. Infliximab (Remicade) is the top selling monoclonal antibody in 2002 which was developed by Centocor and is marketed by Centocor and Schering-Plough for the treatment of rheumatoid arthritis (RA) and Crohns disease. Rituximab (Rituxan), developed by Genentech and IDEC and marketed by Genentech, IDEC and Roche, for the treatment of non-Hodgkins lymphoma, is the second largest selling monoclonal antibody.[21] Vaccines: Vaccines are antigenic proteins which are either partial or modified form of bacteria, viruses and toxins which causes certain diseases against which vaccine protects. The antigenic property of vaccines is altered from its original form by certain processes such as utilizing attenuated viruses, inactivated viruses, part of a virus or bacteria and toxin produced by bacteria; hence they lack ability to cause disease although, endures ability to produce an immune response.[22] Vaccines are the only known prophylactic approach which are commonly available to cure many infective diseases. Vaccines cover the global market share of $ 3 billion annually. Government health agencies run different immunization programs which alleviate the risk of many infective disorders. However, there are approximately 15 million people die every year from certain infectious diseases that can be cured by vaccination process. Pharmaceutical and biopharmaceutical industries seek great potential in this area but the use is limited because of their high production cost, delivery and distribution problems. Vaccines may contain animal derived products such as Bovine serum albumin or fetal calf serum or human derived product for example using cell lines of human tissues. However in recent years transgenic and recombinant plants are also utilized for the production of vaccines.[12,23,24] There are different vaccines available in the market for many infectious diseases such as poliomyelitis, cholera, diphtheria, tetanus, hepatitis B, hepatitis A, measles, meningitis etc. For hepatitis B virus some examples are Baraclude (Entecavir ®), Adefovir dipivoxil (Hepsera ®), Lamivudine (Epivir ®-HBV, 3TC), Alfa Interferon (Intron ® A, Infergen ®, Roferon ®).[1,25] Antisense drugs: Antisense compounds are non-coding strand of messenger RNA(mRNA), which hybridize with mRNA and inactivates the ability of genes to produce the protein for which it holds the recipe.[26] They do not alter human gene causing variation in human genetic information. It was first developed in 1978 using a string of DNA nucleotide which binds with messenger RNA and block its function. These drugs are designed to treat a wide range of diseases such inflammatory, infectious, cancer and cardiovascular diseases. Fomiversen was the first antisense drug approved in 1998 for the treatment of cytomegalovirus retinits in AIDS patients. These are categorized under three sub-classes i.e. antisense oligonucleotides(ASONs), ribozymes and RNA interference(RNAi). Affinitak, manufactured by ISIS pharmaceuticals and Eli Lilly, is used for the treatment of non-small-cell lung carcinoma(NSCLC). There are certain antisense compound are under review by health agencies for their therapeutic efficacy towards ma ny anomalies[27,28] Peptide therapeutics: Peptides are polymers having one or two amino acids linked with amides and are chemically synthesized by using liquid phase or solid phase synthesis. Their chemical synthesis is preferred over biosynthetic approach because it facilitates the conjugation or incorporation of small molecules and non-natural amino acids. This approach reveals the potential of such molecules as cytotoxic agents for antitumor therapy. Peptides with non-natural opens up the possibility for greater chemical diversity, analogous to small-molecule medicinal chemistry approaches for developing high-af ¬Ã‚ nity, highspeci ¬Ã‚ city molecular recognition. Cationic antimicrobial peptides (CAMPs) and peptidoglycan recognition proteins (PGRPs)are developed from the effectors of innate immune response in eukaryotes during their defense mechanism. However there are not many products of peptides found in the market but researchers are trying to develop some therapeutic peptides and proteins with significant effect towards certain diseases. Nesiritide (Natrecor, Noratak) is produced by Johnson Johnson2001, Teriparatide (Forteo) is developed and marketed by Lily in 2002 Enfuvirtide (Fuzeon) is manufactured by Trimeris 2003.[29-31] Challenges associated with biopharmaceutical products: Biopharmaceutical products such as monoclonal antibodies, vaccines, certain hormones, and cell therapies are rewarded as some of the most promising innovation in the field of medicine and health. However there are certain risk and challenges associated with such products which hamper their performance. One of the major challenges is the purification of proteins although it can be achieved by various processes but still purification of such compound is very critical hence requires a lot of attention during manufacturing. Next generation pharmaceutical.[32] However the whole process is carried out under two phases i.e. upstream and downstream regulation. Immunogenicity associated with some of these proteins is also a major concern for biopharmaceutical agents. A repeated injection of human protein may affect the immune tolerance towards self- antigen, leading to humoral response.[33]   Biopharmaceutical products require greater attention, process level as well as monitory level, in the development phase of the drug discovery process it requires approximately $200 million to develop a biopharmaceutical product hence the risk associated with their failure during development stage is increased. Apart from purification and immunogenicity some other issues also make some impact during their development such as government regulations which influence the cost of such products. As discussed earlier it takes a large amount of money to develop such agents hence companies also compensate their development cost and earn profits from their products, ones marketed, which exponentially increases the cost of the drugs. Last and one of the most important risk associated with such products is the introduction of biosimilar products. Biopharmaceutical market is growing very fast, the initial compounds of the first generation are now coming to an end. The expiry of the patents opens the market for generic products which not only influence the established market of some very popular brands, it also forms a milieu of competition to sell the products at cheaper rates which is compensated by their quality.[34] Conclusion Biopharmaceutical products are one amongst the novel class of therapeutic compounds. These are medical agents obtained from biological sources and some special one are manufactured by biotechnological means. They are cellular products, therapeutic proteins, vaccines, gene therapy products and plasma blood product derivatives. Erythropoietins, insulins, and monoclonal antibodies, are some of the leading biopharmaceutical products available in the market hence biopharmaceutical companies are now focusing on their use in long-term conditions such as cardiovascular disease, diabetes and asthma. The blockbuster sales of some existing biopharmaceutical products accompanied by the tremendous innovation and a plethora of pipeline products demonstrate the vigorous growth in the biopharmaceutical market in upcoming years. This significant growth is supported by some of the key segments of the field like monoclonal antibody and vaccines. In addition approaches like gene therapy and peptide ther apeutics holds enormous potential for some life threatening anomalies and the combined approach of proteomics, genomics and biotechnology is predicted to empower the most part of the healthcare sector in the upcoming days.

Apollinarius and His Teachings Essay -- Religion History

Apollinarianism is the heresy, which denied the completeness of Christ’s humanity named after Apollinarius of Laodicea born circa 312 –315 who became a bishop of Laodicea in 360. Originally, a supporter of orthodoxy against the Arians, his Christological teaching becomes a heresy among scholars, at a synod in Rome in 374-80 and by the Council of Constantinople in 381. The Christology of Apollinarius is summarised as, one hypostasis, one physis, one prosopon and one energia (activity). The intention of this essay is to examine the background of Apollinarius and his teachings. It will also look at his main opponents Gregory of Nazianzus and Gregory of Nyssa. Background: Apollinarius of Laodicea is the last of the great extraordinary thinkers of his time influenced by Hellenic position. Apollinarius was a man of great learning influenced by his father a grammarian also called Apollinarius. His father left his hometown and settled at Berytus as a schoolmaster, and later had moved to Laodicea. Apollinarius formed friendships with influential figures in early church society such as Epiphanius. If Apollinarius was not born in the faith then he had been a Christian for many years. He was then ordained priest at Laodicea. He was familiar with classical literature and wanted his son Apollinarius born between 312 and 315 to have a good education. Not much is known about the life of his son Apollinarius of Laodicea he was enthusiastic to the formulation of the Nicene faith and was left to develop his theological theories, during his life time he made many works which have now perished. The works, which are available to us, are heretical and are just a small proportion of his entire works. Later this city became his Episcopal ... ...t recurring argument against his Christology. â€Å"It was man’s rational soul, with its power of choice, which was the seat of sin†; if the word is un-united with a human rational soul then the salvation of mankind is not achieved. Works Cited Dà ¼nzl Franz, A Brief History of the Doctrine of the Trinity in the Early Church, 2007, London. Grillmeier Aloys, Christ in Christian Tradition, Volume 2, Part one, 1987, Oxford. Grillmeier Aloys, Christ in Christian Tradition, Volume 2, Part two, 1987, Oxford. Kelly J. N. D., Early Christian Doctrines, 2008, London. Raven Charles E., Apollinarianism, 1923, Cambridge. Sellers R. V., Two Ancient Christologies, 1940, London Stevenson J., Creeds, Councils and Controversies, 1989, London. Norris R. A. Jr., The Christological Controversy, 1980, Oxford. Addis & Arnold, Catholic Dictionary, 1951, London.

Dbq Essay on Geographies Affects on the World

Geography DBQ The ancient world is very unique, and in some ways tough to figure out. The hardest part of solving the mysteries of ancient times is getting in the minds of the people living back then. No one can completely understand the full effect of a regions geography on the shaping of civilization. The only way we can fully comprehend a civilizations reliance on geography is by reading into it. Through documents and maps we can start to understand the impact geography had on a civilizations economical, spiritual and agriculture development.Agricultural is the easiest thing to crack when trying to figure out the development of a city in ancient times. Maps provide the best information on a regions geography, it gives knowledge of possible places where humans could’ve used certain skills to their advantage or to invent new techniques to use against the downfalls of a certain area. An informative map of present day china educates the general public on the physical qualities of a region (2). This document is unprejudiced because it is a map, it was created to simply show people what China looks like, it’s facts. he reason for The Legend of Yu was to entertain the public by creatively explaining how rivers and seas were created in China (4). This is a fictional story, therefore it is biased. Spodek’s map in The World’s History is informing readers on where some of the most abundant crops and animals could be located around the world (8). Although nothing can be proven completely, this map is a very good piece of work present-day historians can use. The map in document 9 is very informative and educates the public about the fertile crescent, the mesopotamian area, located in the middle east (9).Unbiased and proven, this document, along with the three other ones mentioned are just a few examples of ways scholars may be able to investigate further into the agriculture of ancient times. Economy of cities in ancient times is a little toug her to figure out. Since everyone from those times is dead, the only way to even get any information is by reading saved documents from those specific times. Although the economies of cities have changed drastically through times, some current systems were used back then. The tough part is figuring out how those systems were created. Proven, informative statistics such as those in doc. ne, reveal to the public some of the ways people back then survived when it came to gathering food and figuring out ways to make everyday living a little simpler (1). People back then had to create some type of tools in order to get dinner and survive everyday. In the Epic of Gilgamesh the author attempts to entertain his readers by telling a story about a leader who forces is people to build a wall in order to protect them from attacks (3). Nobody wanted their city to be taken under control by someone else, even in present day we do everything we can to protect where we live. eography can really infl uence the successfulness of keeping your city under control and safe from others. Building new structures such as temples and houses was greatly affected by geography. The picture of Mohenjo daro displays the structures built there and educates the public on what common buildings looked like (6). Mountains, rivers, land, all these can affect the success of an economy. You never know what could happen and although ancient people didn’t have all the technology we do to predict disasters such as earthquakes and tsunamis, their ability to manage without it is very inspiring.One bad thing and a whole city could be destroyed. Figuring out the geographical impact on spirituality is by far the most difficult thing to figure out. Ancient people could only pray to Gods to protect their land. The author of â€Å"Hymn of the Nile† is thanking the Nile river for doing all the wonderful things it has done, although this document is biased it is still very appreciative (5). People be lieved and still do believe that praying and thanking gods will result in good things happening to them. Praying for rain, or good crops, or many animals was not something new.In a criticizing tone, followers of Jesus accused the public of taking advantage of God’s generosity of gifts that don’t even belong to them (7). Because of the fact they can’t prove people are taking advantage and they’re just basing these accusations off of their beliefs, this document is biased. I’m not sure if we will ever be able to have a complete understanding of the affects geography can have on the development of a civilizations economical, agriculture and spiritual lives, it won’t stop historians from investigating. There is so much out there to learn about and the deeper you dig, the more you find.

Cat Vs. Dog Essays - Cat, Dog, Poodle, Litter Box, Pet, Cat Behavior

Cat Vs. Dog Essays - Cat, Dog, Poodle, Litter Box, Pet, Cat Behavior Cat Vs. Dog The Cat Versus The Dog There comes a time in most everyones life when he or she decides to buy a pet. Some people go for the unusual and choose a bird, snake, or rodent. Most people, however, decide on the more common four-legged creatures like a dog or cat. Dogs and cats are very different animals and they have different attitudes, needs, and habits. Understanding these differences can help in the process of choosing between them. For unwavering love and loyalty, not to mention protection, a dog is the choice. Dogs will not question authority, and they will, after some training, do exactly what they are told to do. There are many species of dogs, and they come in large, medium, and small sizes. Smaller sizes like poodles and bichons for people who just need an extra friends and bigger dogs like rottweilers and mastiffs for those who are in need of further protection. Dogs require a lot of attention, and they will make sure their owners are aware of it. They need to be watched constantly and must be taken regularly for walks, because, as most owners know, a dog cannot be trained to do his business in a litter box. A dog will, however, respond instantly to his owner's every wish and will lie at or on that owner's feet anytime, anywhere. A dog is very much like a child in that it cannot be left alone in the house for too long. It will get bored easily and can, without too much effort, make your house look as if a tornado were just there. On the other hand, for ease of care, or peace and quiet, cats can be a better choice. Cats will not question authority; they wont even listen to it. There are many species of cats, but their size will generally be the same for all breeds. They will only sleep on the bed if they want to, and will sleep at whichever end they choose. Cats are quite independent, and they do not require much attention over and above regular feeding and regular cleaning of the litter box. It is a comfort to the owner to know that the cat is simply there, and although a cat rarely responds to an owner's call, it will show affection by nuzzling or rubbing with its entire body. The purring sound a cat makes when it is content is one of the few indications of its love. Perhaps to compensate for their reticent nature, cats grow up quickly and are able to amuse themselves all day while their owners are away. They will only make a mess of the house if they are upset or sick. Cats and dogs make wonderful pets, and they both give many years of companionship. They are soothing to the soul, and they teach responsibility. The decision regarding which to choose, then, is one of duty. The pet owner must decide how much effort he or she wants to put forth. If a loyal, loving pet and trustworthy companion is desired, the dog is a good choice. If, conversely, quiet and low maintenance is more important, a cat is a better choice.

Sound and Music in Video Games essays

Sound and Music in Video Games essays As with film, television, and other primarily visual media, sound and music are often the forgotten elements in video game design. That may be because sound affects humans more subtly than splashy visuals. In fact, often times the mark of superior sound design is that one does not consciously notice it. Instead, it goes to work on ones subconscious-heightening tension, manipulating the mood and drawing the player into the game world. This essay is an exploration into video game sounds: how time and technological development has changed them, as well as what is involved when creating a video game soundtrack. A BRIEF HISTORY OF SOUND IN VIDEO GAMES In 1972, Pong the first video game which includes sound comes onto the market. Six years later the game space invaders hits arcades with its menacing, paranoia-inducing soundtrack. It is an example of simple, effective sound design; the thumping audio track actually accelerates in tempo as the enemy invaders draw nearer and move faster. The following year Asteroids another arcade game employs a similar sound technique to achieve the same results. At the beginning of the 80's PacMan makes its debut. The game boasts many memorable sound and music elements; for example Pac-Man dying blinking out which has become the universally accepted sound of "defeat". A year later Donkey Kong comes out with its award winning sound design composed on a small electronic keyboard. In 1985 the Nintendo Entertainment System enters the market with, first, Tetris whose infectious Russian soundtrack adds greatly to the puzzle game's enduring appeal. Followed by Super Mario Bros. whose soundtrack will forever be engraved on the minds of its players which took the first step towards interactive music with a constantly shifting tone to match the action on screen. In 1987 the Legend of Zelda as well as...